anti-CRISPR ID Family Type Status Source of species Comments Reference
anti_CRISPR0499AcrIF11I-FVerifiedMoraxella catarrhalis BC8-- 30190308
anti_CRISPR0500AcrVA2V-AVerifiedMoraxella bovoculiIt inhibits Cas12a 30190308
anti_CRISPR0501AcrVA3V-A,I-CVerifiedMoraxella caviaeIt showed stronger Cas12a inhibition and also showed partial restoration of phage titer during type I-C targeting 30190308
anti_CRISPR0553AcrIIC4II-CVerifiedHaemophilus parainfluenzaeIts expression completely inhibited the activity of HpaCas9 and decreased the activity of NmeCas9 by 100-fold 30514786
anti_CRISPR0554AcrIIC5II-CVerifiedSimonsiella muelleriIts expression completely inhibited the activity of both NmeCas9 and HpaCas9 30514786
anti_CRISPR0555AcrVA1V-AVerifiedMoraxella bovoculiIt inhibited DNA cleavage by all three Cas12a enzymes; the strongest inhibition was observed for MbCas12a, and the weakest was observed for AsCas12a. 30190307
anti_CRISPR0556AcrVA4V-AVerifiedMoraxella bovoculiIt inhibited dsDNA cleavage for both MbCas12a and LbCas12a but did not inhibit AsCas12a. 30190307
anti_CRISPR0557AcrVA5V-AVerifiedMoraxella bovoculiIt inhibited dsDNA cleavage for both MbCas12a and LbCas12a but did not inhibit AsCas12a. 30190307
anti_CRISPR0558AcrIIA7II-AVerifiedmetagenomeIt inhibit SpCas9 activity in our in vitro DNA cleavage assay 30737174
anti_CRISPR0559AcrIIA8II-AVerifiedmetagenomeIt inhibit SpCas9 activity in our in vitro DNA cleavage assay 30737174
anti_CRISPR0560AcrIIA9II-AVerifiedmetagenomeIt inhibit SpCas9 activity in our in vitro DNA cleavage assay 30737174
anti_CRISPR0561AcrIIA10II-AVerifiedmetagenomeIt inhibit SpCas9 activity in our in vitro DNA cleavage assay 30737174
anti_CRISPR1284AcrIIA6II-AVerifiedStreptococcus phage D1811It from S. thermophilus phages inhibit Cas9-mediated genome editing of human cells 30046034
anti_CRISPR1285AcrIIA6II-AVerifiedStreptococcus phage D1024It from S. thermophilus phages inhibit Cas9-mediated genome editing of human cells 30046034
anti_CRISPR1286AcrIIA11II-AVerifiedClostridialesIt inhibits SpyCas9 31502535
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