September 2017: Version 1
The records have five anti-CRISPR activities including AcrIF, AcrIE, AcrIIA, AcrIIC, AcrVIB and can be further divided into 22 families including AcrIF1-10, AcrIE1-4, AcrIIA1-5, AcrIIC1-3. Totally having 432 entries in this version.
May 2018: Version 1.1
Adding AcrIIA5 (PMID: 28785032) and AcrID1 (PMID: 29507349). There are seven Acrs types and 24 families at this time. Totally 485 entries in this version.
July 2018: Version 1.2
Adding AcrIIA6 (PMID: 30046034). There are 7 Acrs types and 25 families at this time. Totally having 487 entries in this version.
January 2019: Version 1.3
Adding AcrVA1-5, AcrIF11-14, AcrIIC4-5 (PMID: 30190308 and PMID: 30190307, PMID: 30514786).
There are 8 Acrs types and 36 families at this time. Totally having 555 entries in this version.
October 2019: Version 1.4
Adding AcrIIA7-11 (PMID: 30737174, PMID: 31502535).
There are 8 Acrs types and 42 families at this time. Totally having 1318 entries in this version.
July 2020: Version 2
1. More Acrs are added including AcrIIIB, AcrIB. Total having 84 families;
2. We added 2305 seqs (called Predicted) that BLASTing via PSIBLAST; 3. 325 entries are confered structures. Totally having 3682 entries in this version.
January 2021: Version 2.1
Cas4 derived from virus and a small pipetide that having an-CRISPR activity were added in the database. Totally having 3684 entries in this version.
May 2021: Version 2.2
Adding the information about probability Estimation for a gene around Acrs.
Proteins complexed with Acrs in 3D structures were added.
The inhibition strength was added.
The inhibition mechanisms were added.
March 2022: Version 2.2
Adding more Acrs, AcrII24-32.1 in our database.Total having 136 verified Acrs