Welcome to Anti-CRISPRdb V2.2
Anti-CRISPR proteins
CRISPR is a tool that is widely used for gene editing. However, unexpected off-target effects may occur as a result of long-term nuclease activity. Anti-CRISPR proteins, which are powerful molecules that inhibit the CRISPR-Cas system, may have the potential to promote better utilization of the CRISPR system in gene editing, especially for gene therapy. Anti-CRISPRdb is the first online resource for organizing these proteins.
New records in version 2.2
Anti-CRISPRdb contains the available protein sequences, DNA sequences, coding regions, source organisms, taxonomy, virulence, and protein interactors and the corresponding three-dimensional structures.
Now version 2.2 contains more information: inhibitory stages and mechanisms, inhibitory ability for Acr-Cas/Acr-CRISPR systems, the estimation of Acr neighbors. Additionally, we also proposed CUBRank, a parameter to measure if a gene is in GIs.
Citation
Chuan Dong, Ge-Fei Hao, Hong-Li Hua, Shuo Liu, Abraham Alemayehu Labena, Guoshi Chai, Jian Huang, Nini Rao, Feng-Biao Guo; Anti-CRISPRdb: a comprehensive online resource for anti-CRISPR proteins, Nucleic Acids Research, gkx835, https://doi.org/10.1093/nar/gkx835